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IASST Develops New Smart Sensor to Control Drug Dosage to Manage Parkinson's Disease

IASST Develops New Smart Sensor to Control Drug Dosage to Manage Parkinson's Disease

The Institute of Advanced Study in Science and Technology (IASST), an autonomous institute of the Department of Science and Technology, has developed an affordable, user-friendly, portable smartphone-based optical sensor system utilizing a fluorescence turn-on mechanism to instantly detect low levels of L-dopa in biological samples.

This portable smartphone-based fluorescence turn-on sensor system assists in managing Parkinson's disease. The sensor would help in accurately detecting the concentration of L-dopa in the body, thereby helping to determine the precise dosage required for effective control of the disease.

Parkinson’s disease is marked by a continuous decrease in neuron cells, which leads to a significant reduction in dopamine (neurotransmitter) levels in our body. L-dopa is a chemical that is converted to dopamine in our body and so acts as an anti-Parkinson’s drug.

It helps compensate for the deficiency of dopamine. As long as the correct amount of L-dopa is administered, the disease remains manageable. However, due to the progressive nature of Parkinson's, as the patient ages, more L-dopa is needed to compensate for the ongoing loss of neurons.

However, too much of the L-Dopa can cause serious side effects like dyskinesia, gastritis, psychosis, paranoia, and orthostatic hypotension, while too little can lead to the return of Parkinson's symptoms.

Considering the critical role of the optimum level of L-dopa in therapy, it is essential to develop a simple, cost-effective, sensitive, and quick method for monitoring L-dopa in biological fluids. This simple, cost-effective, and rapid screening tool is crucial for on-spot analyte detection in remote areas lacking advanced equipment.

By detecting whether biological samples from the patient have low levels of L-Dopa, the sensor could help adjust the required dosage for effective control of the disease.

More news about: engineering | Published by Aishwarya | August - 29 - 2024 | 118

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