T-Maximum Pharmaceutical has received high acclaim from the international medical community for its groundbreaking work in allogeneic CAR-T cell therapy at ASCO Breakthrough 2024.

The company presented an exploratory investigator-initiated trial involving the intrathecal or intracerebroventricular administration of B7H3-specific allogeneic CAR-T cells for the treatment of recurrent high-grade glioma. This study, focused on the use of B7H3-specific allogeneic universal CAR-T cells in patients with recurrent high-grade gliomas, was highlighted at the 2024 American Society of Clinical Oncology (ASCO) Breakthrough Summit. The presentation was honored with an Abstract Award, one of only 40 awarded globally at the conference.

T-Maximum Pharmaceutical was founded in 2017, and two core laboratories are located in China and the United States.

T-Maximum Pharmaceutical is leading the development of universal cell therapies, advancing cell therapy as the definitive treatment for 'untreatable' diseases. T-MAXIMUM is currently focusing on advanced-stage solid malignancies, with its lead pipeline product for recurrent high-grade glioma (rHGG) demonstrating breakthrough efficacy and manageable safety in initial clinical studies and obtained Orphan Drug Designation (ODD) from the US FDA.

The team includes top experts in immunotherapy, gene editing, and seasoned biopharmaceutical professionals. They utilize advanced gene-edited allogeneic immune cell therapy technology to develop universal CAR-T cell therapies. This technology effectively overcomes challenges like Host versus Graft Reaction (HVGR) and Graft versus Host Disease (GvHD), allowing allogeneic CAR-T cells to persist longer in patients and achieve optimal therapeutic outcomes.

Most clinical trials to date have focused on CAR T cell therapies using autologous T cells, which are derived from the patient's own cells. However, this approach presents several challenges. The production process is both time-intensive and expensive, as it requires generating the therapy from each individual patient's cells. This can lead to delays in treatment, which is particularly concerning for patients with rapidly progressing diseases. Additionally, there is a risk of manufacturing failure, further complicating the timely delivery of therapy.

Another obstacle is the condition of the autologous T cells themselves. Patients often receive lymphodepleting chemotherapy or radiotherapy, which can reduce both the quantity and quality of their T cells. Moreover, the diversity of tumor antigen expression and the tumor's ability to evade the immune system necessitate CAR T cell products that can target multiple antigens. Unfortunately, in patients who have undergone extensive prior treatments, the supply of functional autologous T cells may be insufficient.

On the other hand, using T cells from healthy donors (allogeneic T cells) offers distinct advantages. These donor-derived cells are plentiful and fully functional, making it possible to create "off-the-shelf" CAR T cell products. This method not only overcomes the limitations of autologous T-cell therapies but also enables greater scalability and availability for broader patient use.